1I76

COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)

Summary for 1I76

Entry DOI	10.2210/pdb1i76/pdb
Related	1BZS 1I73 1JAP
Descriptor	NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase, complex (metalloprotease-inhibitor)
Biological source	Homo sapiens (human)
Cellular location	Cytoplasmic granule: P22894
Total number of polymer chains	1
Total formula weight	18716.17
Authors	Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. (deposition date: 2001-03-08, release date: 2001-03-21, Last modification date: 2023-08-09)
Primary citation	Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J.Med.Chem., 43:3377-3385, 2000 Cited by PubMed: 10978185 DOI: 10.1021/jm9909589 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation