1I76

COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)

1I76 の概要

• エントリーDOI: 10.2210/pdb1i76/pdb
• 関連するPDBエントリー: 1BZS 1I73 1JAP
• 分子名称: NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, complex (metalloprotease-inhibitor)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasmic granule: P22894
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18716.17

構造登録者

Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. (登録日: 2001-03-08, 公開日: 2001-03-21, 最終更新日: 2023-08-09)

• 主引用文献: Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A.; Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.; J.Med.Chem., 43:3377-3385, 2000; PubMed: 10978185; DOI: 10.1021/jm9909589

実験手法

X-RAY DIFFRACTION (1.2 Å)