1I73
COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Summary for 1I73
Entry DOI | 10.2210/pdb1i73/pdb |
Related | 1BZS 1I76 1JAP |
Descriptor | NEUTROPHIL COLLAGENASE, THREE RESIDUE PEPTIDE INHIBITOR, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | metalloprotease-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 2 |
Total formula weight | 18817.20 |
Authors | Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. (deposition date: 2001-03-07, release date: 2001-03-21, Last modification date: 2023-08-09) |
Primary citation | Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J.Med.Chem., 43:3377-3385, 2000 Cited by PubMed: 10978185DOI: 10.1021/jm9909589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report