1I57

CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT

1I57 の概要

• エントリーDOI: 10.2210/pdb1i57/pdb
• 分子名称: PHOSPHO-TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: substrate-trapping mutant, conformational change, wpd loop, phosphate-binding loop, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36423.68

構造登録者

Scapin, G.,Patel, S.,Patel, V.,Kennedy, B.,Asante-Appiah, E. (登録日: 2001-02-26, 公開日: 2001-08-08, 最終更新日: 2023-08-09)

• 主引用文献: Scapin, G.,Patel, S.,Patel, V.,Kennedy, B.,Asante-Appiah, E.; The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.; Protein Sci., 10:1596-1605, 2001; PubMed: 11468356; DOI: 10.1110/ps.11001

実験手法

X-RAY DIFFRACTION (2.1 Å)