1HTJ

STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF

Summary for 1HTJ

Entry DOI	10.2210/pdb1htj/pdb
Descriptor	KIAA0380 (2 entities in total)
Functional Keywords	rgs-like, regulator of g protein signaling, gef, guanine nucleotide exchange factor, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	23901.24
Authors	Longenecker, K.L.,Lewis, M.E.,Chikumi, H.,Gutkind, J.S.,Derewenda, Z.S. (deposition date: 2000-12-29, release date: 2001-07-11, Last modification date: 2024-11-13)
Primary citation	Longenecker, K.L.,Lewis, M.E.,Chikumi, H.,Gutkind, J.S.,Derewenda, Z.S. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. Structure, 9:559-569, 2001 Cited by PubMed Abstract: The multidomain PDZ-RhoGEF is one of many known guanine nucleotide exchange factors that upregulate Rho GTPases. PDZ-RhoGEF and related family members play a critical role in a molecular signaling pathway from heterotrimeric G protein-coupled receptors to Rho proteins. A approximately 200 residue RGS-like (RGSL) domain in PDZ-RhoGEF and its homologs is responsible for the direct association with Galpha12/13 proteins. To better understand structure-function relationships, we initiated crystallographic studies of the RGSL domain from human PDZ-RhoGEF. PubMed: 11470431 DOI: 10.1016/S0969-2126(01)00620-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation