1HTG

X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE

Summary for 1HTG

Entry DOI	10.2210/pdb1htg/pdb
Descriptor	HIV-1 PROTEASE, 2-(BENZYLCARBAMOYL-PHENYLACETYLAMINO-METHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID 3-[(1H-BENZIMIDAZOL-2-YLMETHYLCARBAMOYL)-1-BENZYL-2-HYDROXYPROPYL]-AMIDE (3 entities in total)
Functional Keywords	hydrolase(acid proteinase)
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
Total number of polymer chains	2
Total formula weight	23131.37
Authors	Jhoti, H.,Wonacott, A.,Murray-Rust, P. (deposition date: 1994-04-29, release date: 1994-07-31, Last modification date: 2024-02-07)
Primary citation	Jhoti, H.,Singh, O.M.,Weir, M.P.,Cooke, R.,Murray-Rust, P.,Wonacott, A. X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. Biochemistry, 33:8417-8427, 1994 Cited by PubMed: 8031777 DOI: 10.1021/bi00194a005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation