1HPV

CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME

1HPV の概要

• エントリーDOI: 10.2210/pdb1hpv/pdb
• 分子名称: HIV-1 PROTEASE, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• 機能のキーワード: hydrolase (acid proteinase)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22113.14

構造登録者

Kim, E.E. (登録日: 1994-11-18, 公開日: 1995-03-31, 最終更新日: 2024-02-07)

• 主引用文献: Kim, E.E.,Baker, C.T.,Dwyer, M.D.,Murcko, M.A.,Rao, B.G.,Tung, R.D.,Navia, M.A.; Crystal Structure of HIV-1 Protease in Complex with Vx-478, a Potent and Orally Bioavailable Inhibitor of the Enzyme; J.Am.Chem.Soc., 117:1181-1182, 1995

実験手法

X-RAY DIFFRACTION (1.9 Å)