1HPO

HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX

Summary for 1HPO

• Entry DOI: 10.2210/pdb1hpo/pdb
• Descriptor: HIV-1 PROTEASE, 4-CYANO-N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYL BENZENSULFONAMIDE (3 entities in total)
• Functional Keywords: hydrolase, acid protease, aspartyl protease
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 2
• Total formula weight: 22114.21

Authors

Watenpaugh, K.D.,Janakiraman, M.N. (deposition date: 1996-12-10, release date: 1997-04-21, Last modification date: 2024-02-07)

• Primary citation: Skulnick, H.I.,Johnson, P.D.,Aristoff, P.A.,Morris, J.K.,Lovasz, K.D.,Howe, W.J.,Watenpaugh, K.D.,Janakiraman, M.N.,Anderson, D.J.,Reischer, R.J.,Schwartz, T.M.,Banitt, L.S.,Tomich, P.K.,Lynn, J.C.,Horng, M.M.,Chong, K.T.,Hinshaw, R.R.,Dolak, L.A.,Seest, E.P.,Schwende, F.J.,Rush, B.D.,Howard, G.M.,Toth, L.N.,Wilkinson, K.R.,Kakuk, T.J.,Johnson, C.W.,Cole, S.L.,Zaya, R.M.,Zipp, G.L.,Possert, P.L.,Dalga, R.J.,Zhong, W.-Z.,Williams, M.G.,Romines, K.R.; Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.; J.Med.Chem., 40:1149-1164, 1997; PubMed: 9089336; DOI: 10.1021/jm960441m

Experimental method

X-RAY DIFFRACTION (2.5 Å)