1HPO
HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10804.8 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE |
| 2 | C (B) | 4-CYANO-N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYL BENZENSULFONAMIDE | non-polymer | 504.6 | 1 | Chemie (UNI) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | engineered mutation |
| Ile 33 | Leu 101 | engineered mutation |
| Ile 63 | Leu 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21609.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 22114.2 |
