1HNW

STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE

1HNW の概要

• エントリーDOI: 10.2210/pdb1hnw/pdb
• 関連するPDBエントリー: 1FJF 1FJG 1HNX 1HNZ 1QD7
• 分子名称: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S9, 30S RIBOSOMAL PROTEIN S10, ... (25 entities in total)
• 機能のキーワード: 30s ribosomal subunit, ribosome, antibiotic, tetracycline
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 22
• 化学式量合計: 788679.84

構造登録者

Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.,Wimberly, B.T.,Ramakrishnan, V. (登録日: 2000-12-08, 公開日: 2001-02-21, 最終更新日: 2024-10-30)

主引用文献

Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.J.,Wimberly, B.T.,Ramakrishnan, V.
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell(Cambridge,Mass.), 103:1143-1154, 2000

PubMed Abstract: We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.

PubMed: 11163189
DOI: 10.1016/S0092-8674(00)00216-6

実験手法

X-RAY DIFFRACTION (3.4 Å)