1HLK
METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR
Summary for 1HLK
Entry DOI | 10.2210/pdb1hlk/pdb |
Descriptor | BETA-LACTAMASE, TYPE II, ZINC ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | alpha-beta structure, beta-sandwich, hydrolase |
Biological source | Bacteroides fragilis |
Cellular location | Periplasm : P25910 |
Total number of polymer chains | 2 |
Total formula weight | 50560.04 |
Authors | Payne, D.J.,Hueso-Rodriguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Chever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Diez, E.,Perez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. (deposition date: 2000-12-01, release date: 2001-11-30, Last modification date: 2023-08-09) |
Primary citation | Payne, D.J.,Hueso-Rodriguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Chever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Diez, E.,Perez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases Antimicrob.Agents Chemother., 46:1880-1886, 2002 Cited by PubMed: 12019104DOI: 10.1128/AAC.46.6.1880-1886.2002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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