1HIV
CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING
Summary for 1HIV
Entry DOI | 10.2210/pdb1hiv/pdb |
Related PRD ID | PRD_000403 |
Descriptor | HIV-1 PROTEASE, 4-[(2R)-3-{[(1S,2S,3R,4S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-4-({(1S,2R)-2-methyl-1-[(pyridin-2-ylmethyl)carbamoyl]butyl}carbamoyl)hexyl]amino}-2-{[(naphthalen-1-yloxy)acetyl]amino}-3-oxopropyl]-1H-imidazol-3-ium (3 entities in total) |
Functional Keywords | acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 2 |
Total formula weight | 22424.47 |
Authors | Thanki, N.,Wlodawer, A. (deposition date: 1992-02-12, release date: 1993-10-31, Last modification date: 2017-11-29) |
Primary citation | Thanki, N.,Rao, J.K.,Foundling, S.I.,Howe, W.J.,Moon, J.B.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Thaisrivongs, S.,Wlodawer, A. Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling. Protein Sci., 1:1061-1072, 1992 Cited by PubMed: 1304383PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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