1HIV

CRYSTAL STRUCTURE OF A COMPLEX OF HIV-1 PROTEASE WITH A DIHYDROETHYLENE-CONTAINING INHIBITOR: COMPARISONS WITH MOLECULAR MODELING

Summary for 1HIV

Entry DOI	10.2210/pdb1hiv/pdb
Related PRD ID	PRD_000403
Descriptor	HIV-1 PROTEASE, 4-[(2R)-3-{[(1S,2S,3R,4S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-4-({(1S,2R)-2-methyl-1-[(pyridin-2-ylmethyl)carbamoyl]butyl}carbamoyl)hexyl]amino}-2-{[(naphthalen-1-yloxy)acetyl]amino}-3-oxopropyl]-1H-imidazol-3-ium (3 entities in total)
Functional Keywords	acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	2
Total formula weight	22424.47
Authors	Thanki, N.,Wlodawer, A. (deposition date: 1992-02-12, release date: 1993-10-31, Last modification date: 2017-11-29)
Primary citation	Thanki, N.,Rao, J.K.,Foundling, S.I.,Howe, W.J.,Moon, J.B.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Thaisrivongs, S.,Wlodawer, A. Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling. Protein Sci., 1:1061-1072, 1992 Cited by PubMed: 1304383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation