1HIG

THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

Summary for 1HIG

Entry DOI	10.2210/pdb1hig/pdb
Descriptor	INTERFERON-GAMMA (1 entity in total)
Functional Keywords	glycoprotein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P01579
Total number of polymer chains	4
Total formula weight	64822.07
Authors	Ealick, S.E.,Cook, W.J.,Vijay-Kumar, S.,Carson, M.,Nagabhushan, T.L.,Trotta, P.P.,Bugg, C.E. (deposition date: 1991-10-03, release date: 1992-04-15, Last modification date: 2024-02-07)
Primary citation	Ealick, S.E.,Cook, W.J.,Vijay-Kumar, S.,Carson, M.,Nagabhushan, T.L.,Trotta, P.P.,Bugg, C.E. Three-dimensional structure of recombinant human interferon-gamma. Science, 252:698-702, 1991 Cited by PubMed Abstract: The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions. PubMed: 1902591 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation