1HIG

THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

1HIG の概要

• エントリーDOI: 10.2210/pdb1hig/pdb
• 分子名称: INTERFERON-GAMMA (1 entity in total)
• 機能のキーワード: glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P01579
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64822.07

構造登録者

Ealick, S.E.,Cook, W.J.,Vijay-Kumar, S.,Carson, M.,Nagabhushan, T.L.,Trotta, P.P.,Bugg, C.E. (登録日: 1991-10-03, 公開日: 1992-04-15, 最終更新日: 2024-02-07)

主引用文献

Ealick, S.E.,Cook, W.J.,Vijay-Kumar, S.,Carson, M.,Nagabhushan, T.L.,Trotta, P.P.,Bugg, C.E.
Three-dimensional structure of recombinant human interferon-gamma.
Science, 252:698-702, 1991

PubMed Abstract: The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.

PubMed: 1902591

実験手法

X-RAY DIFFRACTION (3.5 Å)