1HDF

Evolution of the eye lens beta-gamma-crystallin domain fold

1HDF の概要

• エントリーDOI: 10.2210/pdb1hdf/pdb
• 関連するPDBエントリー: 1AG4
• 分子名称: SPHERULIN 3A, CALCIUM ION (3 entities in total)
• 機能のキーワード: structural protein, crystallins, eye lens, domain interactions, spherulin 3a, tyrosine corner
• 由来する生物種: PHYSARUM POLYCEPHALUM
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22620.99

構造登録者

Clout, N.J.,Kretschmar, M.,Jaenicke, R.,Slingsby, C. (登録日: 2000-11-13, 公開日: 2000-12-28, 最終更新日: 2024-11-06)

主引用文献

Clout, N.J.,Kretschmar, M.,Jaenicke, R.,Slingsby, C.
Crystal Structure of the Calcium-Loaded Spherulin 3A Dimer Sheds Light on the Evolution of the Eye Lens Betagamma-Crystallin Domain Fold
Structure, 9:115-, 2001

PubMed Abstract: The betagamma-crystallins belong to a superfamily of two-domain proteins found in vertebrate eye lenses, with distant relatives occurring in microorganisms. It has been considered that an eukaryotic stress protein, spherulin 3a, from the slime mold Physarum polycephalum shares a common one-domain ancestor with crystallins, similar to the one-domain 3-D structure determined by NMR.

PubMed: 11250196
DOI: 10.1016/S0969-2126(01)00573-1

実験手法

X-RAY DIFFRACTION (2.35 Å)