1HDC

MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR

1HDC の概要

• エントリーDOI: 10.2210/pdb1hdc/pdb
• 分子名称: 3-ALPHA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE, CARBENOXOLONE (3 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Streptomyces exfoliatus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 107845.81

構造登録者

Ghosh, D. (登録日: 1994-10-21, 公開日: 1995-02-07, 最終更新日: 2024-02-07)

主引用文献

Ghosh, D.,Erman, M.,Wawrzak, Z.,Duax, W.L.,Pangborn, W.
Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor.
Structure, 2:973-980, 1994

PubMed Abstract: Bacterial 3 alpha, 20 beta-hydroxysteroid dehydrogenase (3 alpha, 20 beta-HSD) reversibly oxidizes the 3 alpha and 20 beta hydroxyl groups of androstanes and pregnanes and uses nicotinamide adenine dinucleotide as a cofactor. 3 alpha, 20 beta-HSD belongs to a family of short-chain dehydrogenases that has a highly conserved Tyr-X-X-X-Lys sequence. The family includes mammalian enzymes involved in hypertension, digestion, fertility and spermatogenesis. Several members of the enzyme family, including 3 alpha, 20 beta-HSD, are competitively inhibited by glycyrrhizic acid, a steroidal compound found in licorice, and its derivative, carbenoxolone, an anti-inflammatory glucocorticoid.

PubMed: 7866748
DOI: 10.1016/S0969-2126(94)00099-9

実験手法

X-RAY DIFFRACTION (2.2 Å)