1HCP

DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL

1HCP の概要

• エントリーDOI: 10.2210/pdb1hcp/pdb
• 分子名称: HUMAN/CHICKEN ESTROGEN RECEPTOR, ZINC ION (2 entities in total)
• 機能のキーワード: transcription regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8898.98

構造登録者

Schwabe, J.W.R.,Rhodes, D.,Neuhaus, D. (登録日: 1993-11-23, 公開日: 1995-11-23, 最終更新日: 2024-05-22)

主引用文献

Schwabe, J.W.,Chapman, L.,Finch, J.T.,Rhodes, D.,Neuhaus, D.
DNA recognition by the oestrogen receptor: from solution to the crystal.
Structure, 1:187-204, 1993

PubMed Abstract: The steroid/nuclear hormone receptors are a large family of conserved ligand-activated transcription factors that regulate gene expression through binding to response elements upstream of their target genes. Most members of this family bind to DNA as homodimers or heterodimers and recognize the sequence, spacing and orientation of the two half-sites of their response elements. The recognition and discrimination of the sequence and arrangements of these half-sites are mediated primarily by a highly conserved DNA-binding domain.

PubMed: 16100953
DOI: 10.1016/0969-2126(93)90020-H

実験手法

SOLUTION NMR