1HBT

Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor

Summary for 1HBT

• Entry DOI: 10.2210/pdb1hbt/pdb
• Descriptor: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), P596 Inhibitor peptide, ... (4 entities in total)
• Functional Keywords: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35993.08

Authors

Rehse, P.H.,Cygler, M. (deposition date: 1995-04-06, release date: 1995-07-10, Last modification date: 2023-11-15)

• Primary citation: Rehse, P.H.,Steinmetzer, T.,Li, Y.,Konishi, Y.,Cygler, M.; Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.; Biochemistry, 34:11537-11544, 1995; PubMed: 7547884; DOI: 10.1021/bi00036a029

Experimental method

X-RAY DIFFRACTION (2 Å)