1H8T
Echovirus 11
Summary for 1H8T
| Entry DOI | 10.2210/pdb1h8t/pdb |
| Descriptor | ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ECHOVIRUS 11 COAT PROTEIN VP3, ... (7 entities in total) |
| Functional Keywords | virus, echovirus coat protein, echovirus, icosahedral virus |
| Biological source | ECHOVIRUS 11 More |
| Cellular location | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P29813 P29813 P29813 P29813 |
| Total number of polymer chains | 4 |
| Total formula weight | 95554.41 |
| Authors | Stuart, A.,McKee, T.,Williams, P.A.,Harley, C.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M. (deposition date: 2001-02-15, release date: 2002-07-11, Last modification date: 2023-12-13) |
| Primary citation | Stuart, A.,Mckee, T.,Williams, P.A.,Harley, C.,Shen, S.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M. Determination of the Structure of a Decay Accelerating Factor-Binding Clinical Isolate of Echovirus 11 Allows Mapping of Mutants with Altered Receptor Requirements for Infection J.Virol., 76:7694-, 2002 Cited by PubMed Abstract: We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes. PubMed: 12097583DOI: 10.1128/JVI.76.15.7694-7704.2002 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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