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1H8T

Echovirus 11

Summary for 1H8T
Entry DOI10.2210/pdb1h8t/pdb
DescriptorECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ECHOVIRUS 11 COAT PROTEIN VP3, ... (7 entities in total)
Functional Keywordsvirus, echovirus coat protein, echovirus, icosahedral virus
Biological sourceECHOVIRUS 11
More
Cellular locationProtein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P29813 P29813 P29813 P29813
Total number of polymer chains4
Total formula weight95554.41
Authors
Stuart, A.,McKee, T.,Williams, P.A.,Harley, C.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M. (deposition date: 2001-02-15, release date: 2002-07-11, Last modification date: 2023-12-13)
Primary citationStuart, A.,Mckee, T.,Williams, P.A.,Harley, C.,Shen, S.,Stuart, D.I.,Brown, T.D.K.,Lea, S.M.
Determination of the Structure of a Decay Accelerating Factor-Binding Clinical Isolate of Echovirus 11 Allows Mapping of Mutants with Altered Receptor Requirements for Infection
J.Virol., 76:7694-, 2002
Cited by
PubMed Abstract: We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes.
PubMed: 12097583
DOI: 10.1128/JVI.76.15.7694-7704.2002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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