1H1B
Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)
1H1B の概要
エントリーDOI | 10.2210/pdb1h1b/pdb |
関連するPDBエントリー | 1B0F 1HNE 1PPF 1PPG |
分子名称 | LEUKOCYTE ELASTASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID, ... (4 entities in total) |
機能のキーワード | hydrolase, serine protease |
由来する生物種 | HOMO SAPIENS (HUMAN) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 48992.42 |
構造登録者 | Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W. (登録日: 2002-07-05, 公開日: 2002-08-29, 最終更新日: 2023-12-13) |
主引用文献 | Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Shah, P.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W. Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151) J.Med.Chem., 45:3878-, 2002 Cited by PubMed: 12190311DOI: 10.1021/JM020881F 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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