1H03

Human CD55 domains 3 & 4

Summary for 1H03

• Entry DOI: 10.2210/pdb1h03/pdb
• Related: 1H04 1H2P 1H2Q 1M11
• Descriptor: COMPLEMENT DECAY-ACCELERATING FACTOR (2 entities in total)
• Functional Keywords: immune system protein, complement decay accelerating factor, enteroviral receptor, bacterial receptor, ligand for cd97, complement pathway, alternative splicing, gpi-anchor
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 27172.10

Authors

Williams, P.,Chaudhry, Y.,Goodfellow, I.,Billington, J.,Spiller, B.,Evans, D.J.,Lea, S.M. (deposition date: 2002-06-11, release date: 2003-03-20, Last modification date: 2024-11-20)

Primary citation

Williams, P.,Chaudhry, Y.,Goodfellow, I.,Billington, J.,Powell, R.,Spiller, O.,Evans, D.J.,Lea, S.M.
Mapping Cd55 Function. The Structure of Two Pathogen-Binding Domains at 1.7 A
J.Biol.Chem., 278:10691-, 2003

PubMed Abstract: Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

PubMed: 12499389
DOI: 10.1074/JBC.M212561200

Experimental method

X-RAY DIFFRACTION (1.7 Å)