1GZT
Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose
Summary for 1GZT
| Entry DOI | 10.2210/pdb1gzt/pdb |
| Descriptor | FUCOSE-SPECIFIC LECTIN, alpha-L-fucopyranose, CALCIUM ION, ... (4 entities in total) |
| Functional Keywords | lectin, sugar-binding protein, fucose |
| Biological source | PSEUDOMONAS AERUGINOSA |
| Total number of polymer chains | 4 |
| Total formula weight | 48440.87 |
| Authors | Mitchell, E.,Imberty, A.,Gilboa-Garber, N. (deposition date: 2002-06-06, release date: 2002-11-19, Last modification date: 2024-05-01) |
| Primary citation | Mitchell, E.,Houles, C.,Sudakevitz, D.,Wimmerova, M.,Gautier, C.,Perez, S.,Wu, A.M.,Gilboa-Garber, N.,Imberty, A. Structural Basis for Oligosaccharide-Mediated Adhesion of Pseudomonas Aeruginosa in the Lungs of Cystic Fibrosis Patients Nat.Struct.Biol., 9:918-, 2002 Cited by PubMed Abstract: Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics. PubMed: 12415289DOI: 10.1038/NSB865 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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