1GT8

DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID

1GT8 の概要

• エントリーDOI: 10.2210/pdb1gt8/pdb
• 関連するPDBエントリー: 1GTE 1GTH 1H7W 1H7X
• 分子名称: DIHYDROPYRIMIDINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
• 由来する生物種: SUS SCROFA (PIG)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 460669.37

構造登録者

Dobritzsch, D.,Ricagno, S.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. (登録日: 2002-01-14, 公開日: 2002-04-11, 最終更新日: 2019-01-23)

• 主引用文献: Dobritzsch, D.,Ricagno, S.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y.; Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.; J. Biol. Chem., 277:13155-13166, 2002; PubMed: 11796730; DOI: 10.1074/jbc.M111877200

実験手法

X-RAY DIFFRACTION (3.3 Å)