1GSZ
Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Summary for 1GSZ
Entry DOI | 10.2210/pdb1gsz/pdb |
Related | 1SQC 2SQC 3SQC |
Descriptor | SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, ... (4 entities in total) |
Functional Keywords | isomerase, cholesterol biosynthesis, inhibitor oxidosqualene cyclase, monotopic membrane protein |
Biological source | ALICYCLOBACILLUS ACIDOCALDARIUS |
Total number of polymer chains | 3 |
Total formula weight | 217214.54 |
Authors | Lenhart, A.,Weihofen, W.A.,Pleschke, A.E.W.,Schulz, G.E. (deposition date: 2002-01-09, release date: 2003-01-16, Last modification date: 2024-05-08) |
Primary citation | Lenhart, A.,Weihofen, W.A.,Pleschke, A.E.W.,Schulz, G.E. Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071 Chem.Biol., 9:639-, 2002 Cited by PubMed: 12031670DOI: 10.1016/S1074-5521(02)00138-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report