1GSD

GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM

1GSD の概要

• エントリーDOI: 10.2210/pdb1gsd/pdb
• 分子名称: GLUTATHIONE TRANSFERASE A1-1 (2 entities in total)
• 機能のキーワード: transferase (glutathione)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P08263
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102155.70

構造登録者

L'Hermite, G.,Sinning, I.,Cameron, A.D.,Jones, T.A. (登録日: 1995-06-09, 公開日: 1995-09-15, 最終更新日: 2024-02-07)

主引用文献

Cameron, A.D.,Sinning, I.,L'Hermite, G.,Olin, B.,Board, P.G.,Mannervik, B.,Jones, T.A.
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3:717-727, 1995

PubMed Abstract: Glutathione transferases (GSTs) constitute a family of isoenzymes that catalyze the conjugation of the tripeptide glutathione with a wide variety of hydrophobic compounds bearing an electrophilic functional group. Recently, a number of X-ray structures have been reported which have defined both the glutathione- and the substrate-binding sites in these enzymes. The structure of the glutathione-free enzyme from a mammalian source has not, however, been reported previously.

PubMed: 8591048
DOI: 10.1016/S0969-2126(01)00206-4

実験手法

X-RAY DIFFRACTION (2.5 Å)