1GO4

Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.

Summary for 1GO4

• Entry DOI: 10.2210/pdb1go4/pdb
• Related: 1DUJ
• Descriptor: Mitotic spindle assembly checkpoint protein MAD2A, Mitotic spindle assembly checkpoint protein MAD1 (3 entities in total)
• Functional Keywords: mitotic spindle checkpoint, cell cycle, mitosis, nuclear pro
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 140563.48

Authors

Sironi, L.,Mapelli, M.,Jeang, K.T.,Musacchio, A. (deposition date: 2001-10-17, release date: 2002-05-16, Last modification date: 2023-12-13)

• Primary citation: Sironi, L.,Mapelli, M.,Knapp, S.,De Antoni, A.,Jeang, K.T.,Musacchio, A.; Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.; EMBO J., 21:2496-2506, 2002; PubMed: 12006501; DOI: 10.1093/emboj/21.10.2496

Experimental method

X-RAY DIFFRACTION (2.05 Å)