1GJI

Crystal structure of c-Rel bound to DNA

Summary for 1GJI

Entry DOI	10.2210/pdb1gji/pdb
Descriptor	IL-2 CD28RE DNA, C-REL PROTO-ONCOGENE PROTEIN (3 entities in total)
Functional Keywords	nf-kb-dna complex, transcription factor, c-rel homodimer, transcription-dna complex, transcription/dna
Biological source	Gallus gallus (chicken)
Total number of polymer chains	4
Total formula weight	76053.63
Authors	Huang, D.B.,Chen, Y.Q.,Ruetsche, M.,Phelps, C.B.,Ghosh, G. (deposition date: 2001-05-30, release date: 2002-05-30, Last modification date: 2024-04-03)
Primary citation	Huang, D.B.,Chen, Y.Q.,Ruetsche, M.,Phelps, C.B.,Ghosh, G. X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. Structure, 9:669-678, 2001 Cited by PubMed Abstract: The proto-oncogene product c-Rel is a Rel/NF-kappaB family transcription factor that plays a critical role in lymphoid cell development and mediates CD28-induced expression of interleukin 2 (IL-2). The CD28 response element (CD28RE) in the IL-2 enhancer is nonameric and similar to the kappaB DNA target sites recognized by p65 homodimers. PubMed: 11587641 DOI: 10.1016/S0969-2126(01)00635-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation