1GJA
ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
Summary for 1GJA
Entry DOI | 10.2210/pdb1gja/pdb |
Related | 1C5X |
Descriptor | UROKINASE-TYPE PLASMINOGEN ACTIVATOR, CITRIC ACID, N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE, ... (5 entities in total) |
Functional Keywords | selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 protease, structure-based drug design, blood clotting, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 P00749 |
Total number of polymer chains | 2 |
Total formula weight | 31783.13 |
Authors | Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. (deposition date: 2001-04-27, release date: 2002-04-27, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Elrod, K.,Kirtley, M.,Janc, J.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem.Biol., 8:1107-1121, 2001 Cited by PubMed: 11731301DOI: 10.1016/S1074-5521(01)00084-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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