1GIJ

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR

Summary for 1GIJ

Related1GIH 1GII
DescriptorCELL DIVISION PROTEIN KINASE 2, 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, inhibition, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34291.78
Authors
Ikuta, M.,Nishimura, S. (deposition date: 2001-02-06, release date: 2002-02-06, Last modification date: 2011-07-13)
Primary citation
Ikuta, M.,Kamata, K.,Fukasawa, K.,Honma, T.,Machida, T.,Hirai, H.,Suzuki-Takahashi, I.,Hayama, T.,Nishimura, S.
Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
J.Biol.Chem., 276:27548-27554, 2002
PubMed: 11335721 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M102060200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers160.4%10.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report