1GEF

Crystal structure of the archaeal holliday junction resolvase HJC

1GEF の概要

• エントリーDOI: 10.2210/pdb1gef/pdb
• 分子名称: HOLLIDAY JUNCTION RESOLVASE, SULFATE ION (3 entities in total)
• 機能のキーワード: holliday junction resolvase, hjc, hydrolase
• 由来する生物種: Pyrococcus furiosus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 55361.64

構造登録者

Nishino, T.,Komori, K.,Tsuchiya, D.,Ishino, Y.,Morikawa, K. (登録日: 2000-11-08, 公開日: 2001-03-21, 最終更新日: 2023-12-27)

主引用文献

Nishino, T.,Komori, K.,Tsuchiya, D.,Ishino, Y.,Morikawa, K.
Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition.
Structure, 9:197-204, 2001

PubMed Abstract: Homologous recombination is a crucial mechanism in determining genetic diversity and repairing damaged chromosomes. Holliday junction is the universal DNA intermediate whose interaction with proteins is one of the major events in the recombinational process. Hjc is an archaeal endonuclease, which specifically resolves the junction DNA to produce two separate recombinant DNA duplexes. The atomic structure of Hjc should clarify the mechanisms of the specific recognition with Holliday junction and the catalytic reaction.

PubMed: 11286886
DOI: 10.1016/S0969-2126(01)00576-7

実験手法

X-RAY DIFFRACTION (2 Å)