1G7F
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496
Summary for 1G7F
Entry DOI | 10.2210/pdb1g7f/pdb |
Related | 1G7G |
Descriptor | PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 2-{4-[(2S)-2-[({[(1S)-1-CARBOXY-2-PHENYLETHYL]AMINO}CARBONYL)AMINO]-3-OXO-3-(PENTYLAMINO)PROPYL]PHENOXY}MALONIC ACID (3 entities in total) |
Functional Keywords | hydrolase (phosphorylation), tyrosine phosphatase, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35250.10 |
Authors | Bleasdale, J.E.,Ogg, D.,Larsen, S.D. (deposition date: 2000-11-10, release date: 2001-06-06, Last modification date: 2023-08-09) |
Primary citation | Bleasdale, J.E.,Ogg, D.,Palazuk, B.J.,Jacob, C.S.,Swanson, M.L.,Wang, X.Y.,Thompson, D.P.,Conradi, R.A.,Mathews, W.R.,Laborde, A.L.,Stuchly, C.W.,Heijbel, A.,Bergdahl, K.,Bannow, C.A.,Smith, C.W.,Svensson, C.,Liljebris, C.,Schostarez, H.J.,May, P.D.,Stevens, F.C.,Larsen, S.D. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. Biochemistry, 40:5642-5654, 2001 Cited by PubMed: 11341829DOI: 10.1021/bi002865v PDB entries with the same primary citation |
Experimental method |
Structure validation
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