1G61

CRYSTAL STRUCTURE OF M.JANNASCHII EIF6

1G61 の概要

• エントリーDOI: 10.2210/pdb1g61/pdb
• 関連するPDBエントリー: 1G62
• 分子名称: TRANSLATION INITIATION FACTOR 6 (2 entities in total)
• 機能のキーワード: alpha-beta-barrel velcro closure subdomain, structural genomics, psi, protein structure initiative, new york sgx research center for structural genomics, nysgxrc, translation
• 由来する生物種: Methanocaldococcus jannaschii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48962.23

構造登録者

Groft, C.M.,Beckmann, R.,Sali, A.,Burley, S.K.,New York SGX Research Center for Structural Genomics (NYSGXRC) (登録日: 2000-11-02, 公開日: 2000-11-22, 最終更新日: 2024-02-07)

主引用文献

Groft, C.M.,Beckmann, R.,Sali, A.,Burley, S.K.
Crystal structures of ribosome anti-association factor IF6.
Nat.Struct.Biol., 7:1156-1164, 2000

PubMed Abstract: Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.

PubMed: 11101899
DOI: 10.1038/82017

実験手法

X-RAY DIFFRACTION (1.3 Å)