1G5Y
THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER.
Summary for 1G5Y
Entry DOI | 10.2210/pdb1g5y/pdb |
Related | 1FM6 1FM9 1G1U 1LBD |
Descriptor | RETINOIC ACID RECEPTOR RXR-ALPHA, RETINOIC ACID (3 entities in total) |
Functional Keywords | rxralpha ligand binding domain, inactive tetramer with 2 monomers bound with an inactivating isomer of retinoic acid, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P19793 |
Total number of polymer chains | 4 |
Total formula weight | 107272.30 |
Authors | Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Wisely, G.B.,Milburn, M.V.,Xu, H.E. (deposition date: 2000-11-02, release date: 2001-05-02, Last modification date: 2018-04-25) |
Primary citation | Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Wisely, G.B.,Milburn, M.V.,Xu, H.E. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. Genes Dev., 14:2229-2241, 2000 Cited by PubMed: 10970886DOI: 10.1101/gad.802300 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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