1G4J

CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE

Summary for 1G4J

• Entry DOI: 10.2210/pdb1g4j/pdb
• Related: 1g1d 1g3z 1g45 1g46 1g48
• Descriptor: CARBONIC ANHYDRASE II, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase ii, f131v, 4-(aminosulfonyl)-n-[(2, 3, 4, 5, 6-pentafluorophenyl)methyl]-benzamide, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 30136.40

Authors

Kim, C.-Y.,Chang, J.S.,Doyon, J.B.,Baird Jr., T.T.,Fierke, C.A.,Jain, A.,Christianson, D.W. (deposition date: 2000-10-27, release date: 2000-11-08, Last modification date: 2024-02-07)

• Primary citation: Kim, C.-Y.,Chang, J.S.,Doyon, J.B.,Baird Jr., T.T.,Fierke, C.A.,Jain, A.,Christianson, D.W.; Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II; J.Am.Chem.Soc., 122:12125-12134, 2000; DOI: 10.1021/ja002627n

Experimental method

X-RAY DIFFRACTION (1.84 Å)