1G37

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE

Summary for 1G37

Entry DOI	10.2210/pdb1g37/pdb
Descriptor	ALPHA THROMBIN, THROMBIN NONAPEPTIDE INHIBITOR, 3-(4-AMINO-CYCLOHEXYL)-2-HYDROXY-3-[(4-OXO-2-PHENYLMETHANESULFONYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE-6-CARBONYL)-AMINO]-PROPIONIC ACID BUTYL ESTER, ... (4 entities in total)
Functional Keywords	protease, thrombin, inhibitor, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P00734
Total number of polymer chains	2
Total formula weight	34720.86
Authors	Bachand, B.,Tarazi, M.,St-Denis, Y.,Edmunds, J.J.,Winocour, P.D.,Leblond, L.,Siddiqui, M.A. (deposition date: 2000-10-23, release date: 2001-04-21, Last modification date: 2023-08-09)
Primary citation	Bachand, B.,Tarazi, M.,St-Denis, Y.,Edmunds, J.J.,Winocour, P.D.,Leblond, L.,Siddiqui, M.A. Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors. Bioorg.Med.Chem.Lett., 11:287-290, 2001 Cited by PubMed: 11212093 DOI: 10.1016/S0960-894X(00)00636-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation