1G2F

STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (TATAZF;CLONE #6)

1G2F の概要

• エントリーDOI: 10.2210/pdb1g2f/pdb
• 関連するPDBエントリー: 1AAY 1G2D
• 分子名称: 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ... (5 entities in total)
• 機能のキーワード: phage display, zinc finger-dna complex, tata box, cys2his2, transcription-dna complex, transcription/dna
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Nucleus : P08046
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 41247.80

構造登録者

Wolfe, S.A.,Grant, R.A.,Elrod-Erickson, M.,Pabo, C.O. (登録日: 2000-10-18, 公開日: 2001-09-07, 最終更新日: 2024-04-03)

主引用文献

Wolfe, S.A.,Grant, R.A.,Elrod-Erickson, M.,Pabo, C.O.
Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9:717-723, 2001

PubMed Abstract: Several methods have been developed for creating Cys2His2 zinc finger proteins that recognize novel DNA sequences, and these proteins may have important applications in biological research and gene therapy. In spite of this progress with design/selection methodology, fundamental questions remain about the principles that govern DNA recognition. One hypothesis suggests that recognition can be described by a simple set of rules--essentially a "recognition code"--but careful assessment of this proposal has been difficult because there have been few structural studies of selected zinc finger proteins.

PubMed: 11587646
DOI: 10.1016/S0969-2126(01)00632-3

実験手法

X-RAY DIFFRACTION (2 Å)