1FV2
The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B
Summary for 1FV2
Entry DOI | 10.2210/pdb1fv2/pdb |
Related | 1a8d 1af9 1d0h 1dfq 1diw 1dll 1fv3 |
Descriptor | TETANUS TOXIN HEAVY CHAIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-beta-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | toxin, carbohydrate, ganglioside, multi-valent binding, receptor |
Biological source | Clostridium tetani |
Total number of polymer chains | 1 |
Total formula weight | 55776.39 |
Authors | Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W. (deposition date: 2000-09-18, release date: 2001-09-05, Last modification date: 2020-07-29) |
Primary citation | Fotinou, C.,Emsley, P.,Black, I.,Ando, H.,Ishida, H.,Kiso, M.,Sinha, K.A.,Fairweather, N.F.,Isaacs, N.W. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J.Biol.Chem., 276:32274-32281, 2001 Cited by PubMed: 11418600DOI: 10.1074/jbc.M103285200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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