1FSG

TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH 9-DEAZAGUANINE, ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) AND TWO MG2+ IONS

Summary for 1FSG

• Entry DOI: 10.2210/pdb1fsg/pdb
• Related: 1BZY 1DBR 1HMP 1QK3 1QK4 1QK5 1TC2
• Descriptor: HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ... (5 entities in total)
• Functional Keywords: glycosyltransferase, purine salvage, transferase
• Biological source: Toxoplasma gondii
• Cellular location: Cytoplasm: Q26997
• Total number of polymer chains: 2
• Total formula weight: 54588.64

Authors

Heroux, A.,White, E.L.,Ross, L.J.,Kuzin, A.P.,Borhani, D.W. (deposition date: 2000-09-08, release date: 2000-12-06, Last modification date: 2024-04-03)

Primary citation

Heroux, A.,White, E.L.,Ross, L.J.,Kuzin, A.P.,Borhani, D.W.
Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
Structure Fold.Des., 8:1309-1318, 2000

PubMed Abstract: Hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) are well-recognized antiparasitic drug targets. HGPRT is also a paradigmatic representative of the phosphoribosyltransferase family of enzymes, which includes other important biosynthetic and salvage enzymes and drug targets. To better understand the reaction mechanism of this enzyme, we have crystallized HGPRT from the apicomplexan protozoan Toxoplasma gondii as a ternary complex with a substrate and a substrate analog.

PubMed: 11188695
DOI: 10.1016/S0969-2126(00)00546-3

Experimental method

X-RAY DIFFRACTION (1.05 Å)