1FSG

TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH 9-DEAZAGUANINE, ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) AND TWO MG2+ IONS

1FSG の概要

• エントリーDOI: 10.2210/pdb1fsg/pdb
• 関連するPDBエントリー: 1BZY 1DBR 1HMP 1QK3 1QK4 1QK5 1TC2
• 分子名称: HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ... (5 entities in total)
• 機能のキーワード: glycosyltransferase, purine salvage, transferase
• 由来する生物種: Toxoplasma gondii
• 細胞内の位置: Cytoplasm: Q26997
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54588.64

構造登録者

Heroux, A.,White, E.L.,Ross, L.J.,Kuzin, A.P.,Borhani, D.W. (登録日: 2000-09-08, 公開日: 2000-12-06, 最終更新日: 2024-04-03)

主引用文献

Heroux, A.,White, E.L.,Ross, L.J.,Kuzin, A.P.,Borhani, D.W.
Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
Structure Fold.Des., 8:1309-1318, 2000

PubMed Abstract: Hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) are well-recognized antiparasitic drug targets. HGPRT is also a paradigmatic representative of the phosphoribosyltransferase family of enzymes, which includes other important biosynthetic and salvage enzymes and drug targets. To better understand the reaction mechanism of this enzyme, we have crystallized HGPRT from the apicomplexan protozoan Toxoplasma gondii as a ternary complex with a substrate and a substrate analog.

PubMed: 11188695
DOI: 10.1016/S0969-2126(00)00546-3

実験手法

X-RAY DIFFRACTION (1.05 Å)