1FQ4
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A
Summary for 1FQ4
Entry DOI | 10.2210/pdb1fq4/pdb |
Related | 1dpj 1fq5 1fq6 1fq7 1fq8 2jxr |
Related PRD ID | PRD_000563 |
Descriptor | SACCHAROPEPSIN, beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2R)-1-{[(2S,3R,5R)-1-cyclohexyl-3-hydroxy-5-{[2-(morpholin-4-yl)ethyl]carbamoyl}oct-7-yn-2-yl]amino}-3-(methylsulfa nyl)-1-oxopropan-2-yl]-1H-benzimidazole-2-carboxamide, ... (5 entities in total) |
Functional Keywords | aspartic proteinase-inhibitor complex, extended beta-strand (inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 37547.42 |
Authors | Cronin, N.B.,Badasso, M.O.,Tickle, I.J.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B. (deposition date: 2000-09-03, release date: 2000-09-20, Last modification date: 2020-07-29) |
Primary citation | Cronin, N.B.,Badasso, M.O.,J Tickle, I.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B. X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity. J.Mol.Biol., 303:745-760, 2000 Cited by PubMed: 11061973DOI: 10.1006/jmbi.2000.4181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report