1FHI
SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT
Summary for 1FHI
Entry DOI | 10.2210/pdb1fhi/pdb |
Descriptor | FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE (3 entities in total) |
Functional Keywords | nucleotide-binding protein, cancer, diadenosine triphosphate hydrolase, histidine triad, tumor suppressor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49789 |
Total number of polymer chains | 1 |
Total formula weight | 17656.70 |
Authors | Pace, H.C.,Garrison, P.N.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Huebner, K.,Brenner, C. (deposition date: 1997-12-11, release date: 1998-06-17, Last modification date: 2024-05-22) |
Primary citation | Pace, H.C.,Garrison, P.N.,Robinson, A.K.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Huebner, K.,Brenner, C. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proc.Natl.Acad.Sci.USA, 95:5484-5489, 1998 Cited by PubMed: 9576908DOI: 10.1073/pnas.95.10.5484 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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