1FFI
STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Summary for 1FFI
Entry DOI | 10.2210/pdb1ffi/pdb |
Related | 1a94 1daz |
Related PRD ID | PRD_000398 |
Descriptor | PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total) |
Functional Keywords | hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22250.37 |
Authors | Mahalingam, B.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2000-07-25, release date: 2001-06-01, Last modification date: 2024-03-13) |
Primary citation | Mahalingam, B.,Louis, J.M.,Hung, J.,Harrison, R.W.,Weber, I.T. Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43:455-464, 2001 Cited by PubMed: 11340661DOI: 10.1002/prot.1057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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