1F7T

HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A

1F7T の概要

• エントリーDOI: 10.2210/pdb1f7t/pdb
• 関連するPDBエントリー: 1F7L
• 分子名称: HOLO-(ACYL CARRIER PROTEIN) SYNTHASE, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: 9-strand pseudo beta barrel, lipid synthesis, transferase
• 由来する生物種: Bacillus subtilis
• 細胞内の位置: Cytoplasm : P96618
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 83963.05

構造登録者

Parris, K.D.,Lin, L.,Tam, A.,Mathew, R.,Hixon, J.,Stahl, M.,Fritz, C.C.,Seehra, J.,Somers, W.S. (登録日: 2000-06-27, 公開日: 2001-06-27, 最終更新日: 2024-02-07)

主引用文献

Parris, K.D.,Lin, L.,Tam, A.,Mathew, R.,Hixon, J.,Stahl, M.,Fritz, C.C.,Seehra, J.,Somers, W.S.
Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
Structure Fold.Des., 8:883-895, 2000

PubMed Abstract: Holo-(acyl carrier protein) synthase (AcpS), a member of the phosphopantetheinyl transferase superfamily, plays a crucial role in the functional activation of acyl carrier protein (ACP) in the fatty acid biosynthesis pathway. AcpS catalyzes the attachment of the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to the sidechain of a conserved serine residue on apo-ACP.

PubMed: 10997907
DOI: 10.1016/S0969-2126(00)00178-7

実験手法

X-RAY DIFFRACTION (1.8 Å)