1F6T
STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX
Summary for 1F6T
Entry DOI | 10.2210/pdb1f6t/pdb |
Related | 1F3F 1LWX |
Descriptor | PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE), MAGNESIUM ION, 2*-DEOXY-THYMIDINE-5*-ALPHA BORANO DIPHOSPHATE (ISOMER RP), ... (4 entities in total) |
Functional Keywords | nucleoside diphosphate kinase, anti-hiv nucleoside analogue, phosphorylation, boranophosphate, transferase |
Biological source | Dictyostelium discoideum |
Cellular location | Cytoplasm: P22887 |
Total number of polymer chains | 3 |
Total formula weight | 51722.00 |
Authors | Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B.,Schneider, B.,Sarfati, S.,Deville-Bonne, D. (deposition date: 2000-06-23, release date: 2000-09-13, Last modification date: 2024-02-07) |
Primary citation | Meyer, P.,Schneider, B.,Sarfati, S.,Deville-Bonne, D.,Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B. Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase. EMBO J., 19:3520-3529, 2000 Cited by PubMed: 10899107DOI: 10.1093/emboj/19.14.3520 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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