1F0C

STRUCTURE OF THE VIRAL SERPIN CRMA

1F0C の概要

• エントリーDOI: 10.2210/pdb1f0c/pdb
• 分子名称: ICE INHIBITOR, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• 機能のキーワード: apoptosis, caspase inhibitor, protease inhibitor, serpin, viral protein
• 由来する生物種: Cowpox virus; 詳細
• 細胞内の位置: Host cytoplasm : P07385 P07385
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38282.36

構造登録者

Renatus, M.,Zhou, Q.,Stennicke, H.R.,Snipas, S.J.,Turk, D.,Bankston, L.A.,Liddington, R.C.,Salvesen, G.S. (登録日: 2000-05-15, 公開日: 2000-09-06, 最終更新日: 2024-02-07)

主引用文献

Renatus, M.,Zhou, Q.,Stennicke, H.R.,Snipas, S.J.,Turk, D.,Bankston, L.A.,Liddington, R.C.,Salvesen, G.S.
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold.Des., 8:789-797, 2000

PubMed Abstract: Cowpox virus expresses the serpin CrmA (cytokine response modifier A) in order to avoid inflammatory and apoptotic responses of infected host cells. The targets of CrmA are members of the caspase family of proteases that either initiate the extrinsic pathway of apoptosis (caspases 8 and 10) or trigger activation of the pro-inflammatory cytokines interleukin-1beta and interleukin-18 (caspase 1).

PubMed: 10903953
DOI: 10.1016/S0969-2126(00)00165-9

実験手法

X-RAY DIFFRACTION (2.26 Å)