1EXA

ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394.

Summary for 1EXA

Related1EXX 2LBD 3LBD 4LBD
DescriptorRETINOIC ACID RECEPTOR GAMMA-2, R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE, ... (4 entities in total)
Functional Keywordsenantiomer discrimination, retinoid ligand complexes, antiparallel alpha-helical sandwich fold, structural proteomics in europe, spine, structural genomics, gene regulation
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight28800.57
Authors
Klaholz, B.P.,Mitschler, A.,Belema, M.,Zusi, C.,Moras, D.,Structural Proteomics in Europe (SPINE) (deposition date: 2000-05-02, release date: 2000-06-09, Last modification date: 2011-07-13)
Primary citation
Klaholz, B.P.,Mitschler, A.,Belema, M.,Zusi, C.,Moras, D.
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Proc.Natl.Acad.Sci.USA, 97:6322-6327, 2000
PubMed: 10841540 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.97.12.6322
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.59 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243701.0%6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-09-16