1EX8

CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR

1EX8 の概要

• エントリーDOI: 10.2210/pdb1ex8/pdb
• 関連するPDBエントリー: 1CBK 1DY3 1EQ0 1EQM 1EQO 1HKA
• 分子名称: 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: pyrophosphokinase, pyrophosphoryl transfer, folate, hppk, pterin, atp, bisubstrate-mimicking inhibitor, antimicrobial agent, drug design, substrate specificity, active-site architecture, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18790.62

構造登録者

Blaszczyk, J.,Ji, X. (登録日: 2000-05-01, 公開日: 2001-05-01, 最終更新日: 2023-08-30)

• 主引用文献: Shi, G.,Blaszczyk, J.,Ji, X.,Yan, H.; Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies.; J.Med.Chem., 44:1364-1371, 2001; PubMed: 11311059; DOI: 10.1021/jm0004493

実験手法

X-RAY DIFFRACTION (1.85 Å)