1EX4

HIV-1 INTEGRASE CATALYTIC CORE AND C-TERMINAL DOMAIN

1EX4 の概要

• エントリーDOI: 10.2210/pdb1ex4/pdb
• 分子名称: INTEGRASE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE (3 entities in total)
• 機能のキーワード: sh3-like domain, nonspecific dna binding beta sheet, cis-proline, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55313.53

構造登録者

Chen, J.C.-H.,Krucinski, J.,Miercke, L.J.W.,Finer-Moore, J.S.,Tang, A.H.,Leavitt, A.D.,Stroud, R.M. (登録日: 2000-04-28, 公開日: 2000-06-07, 最終更新日: 2024-02-07)

• 主引用文献: Chen, J.C.,Krucinski, J.,Miercke, L.J.,Finer-Moore, J.S.,Tang, A.H.,Leavitt, A.D.,Stroud, R.M.; Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.; Proc.Natl.Acad.Sci.USA, 97:8233-8238, 2000; PubMed: 10890912; DOI: 10.1073/pnas.150220297

実験手法

X-RAY DIFFRACTION (2.8 Å)