1EWP
CRUZAIN BOUND TO MOR-LEU-HPQ
Summary for 1EWP
Entry DOI | 10.2210/pdb1ewp/pdb |
Related | 1aim 1ewl 1ewm 1ewo 2aim |
Related PRD ID | PRD_000312 |
Descriptor | CRUZAIN, N-[(3S)-1-fluoro-2-oxo-5-phenylpentan-3-yl]-N~2~-(morpholin-4-ylcarbonyl)-L-leucinamide (3 entities in total) |
Functional Keywords | cysteine protease, drug design, covalent inhibitor, cruzipain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 23136.64 |
Authors | Gillmor, S.A. (deposition date: 2000-04-26, release date: 2000-05-17, Last modification date: 2024-03-13) |
Primary citation | Gillmor, S.A. Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors Enzyme-ligand Interactions, Inhibition and Specificity, :50-80, 1998 Cited by |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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